Superoxide anion mediates the endothelium-dependent contractions to serotonin by regenerated endothelium

Endothelium-dependent contractions: from superoxide anions to TP-receptor agonists -

Endothelium modulates anion channel-dependent aortic contractions to iodide.

Anion currents contribute to vascular smooth muscle (VSM) membrane potential. The substitution of extracellular chloride (Cl) with iodide (I) or bromide (Br) initially inhibited and then potentiated isometric contractile responses of rat aortic rings to norepinephrine. Anion substitution alone produced a small relaxation, which occurred despite a lack of active tone and minimal subsequent contr...

Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent

Relaxation : Role of gp91phox Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000038108.71560.7

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded area or from the proximal left circumflex coronary artery. The experiments wer...

Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent Relaxation Role of gp91

Background—Like endothelial and smooth muscle cells, vascular adventitial fibroblasts contain a substantial NAD(P)H oxidase superoxide anion (O2 )-generating system activated by angiotensin II (Ang II). Based on the ability of nitric oxide (NO·) to diffuse rapidly through tissue and the fast reaction rate of NO· and O2 , we postulated that the interaction between NO· and adventitial NAD(P)H oxi...